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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   2

Issue No. :  4

Year :  2009

Pages :   

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Simultaneous RP-HPLC Method for Estimation of Metformin Hydrochloride and Fenofibrate in Synthetic Mixture



Address:   Department of Pharmaceutical Chemistry, Pad. Dr. D.Y.Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune-411 018, Maharashtra, India
DOI No: Not Available

ABSTRACT:
The proposed method is a simple, accurate, precise, specific and rapid method for the simultaneous estimation of Metformin hydrochloride and Fenofibrate in bulk and synthetic mixture using C18 column (Kromosil, 4.6mm x 25 cm, 5µm) with Acetonitrile: 0.02 M Ammonium acetate buffer (80: 20 v/v) as a mobile phase, at a flow rate of 1.0 ml/min and detection was done at 249.0 nm. The retention time for metformin hydrochloride and fenofibrate was found to be 2.63+ 0.011and 9.26+ 0.017 min. respectively. Linearity of metformin hydrochloride and fenofibrate were found in the range of 5–50 μg/ml and 0.8-8.0 μg/ml respectively. The percentage assay of metformin hydrochloride and fenofibrate was found between 98% to 102 %.The statistical parameters were found satisfactory.
KEYWORDS:
Metformin hydrochloride (MET), Fenofibrate (FNB), RP-HPLC
Cite:
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