List of Refereed Journals published by UGC, New Delhi on 28-03-2017-- AJRC (Sr. No.-1025); AJM (Sr. No.-2497); RJET (Sr. No.-7220); RJPP (Sr. No.- 7232): RJPPD (Sr. No.- 7234); RJPT (Sr. No.-7235) (19-Apr-2017)        | List of Refereed Journals published by UGC, New Delhi on 11-01-2017-- Research Journal of Pharmacy and Technology (Sr. No.-275); Asian Journal of Management (Sr. No.-3986); Asian Journal of Research in Chemistry (Sr. No.-4008); Research Journal of Engineering and Technology (Sr. No.-31787); Research (22-Jan-2017)        |

Journal :   Research Journal of Pharmacy and Technology

Volume No. :   2

Issue No. :  4

Year :  2009

Pages :   

ISSN Print :  0974-3618

ISSN Online :  0974-360X


Registration

Allready Registrered
Click to Login

Formulation and Evaluation of Mucoadhesive Buccal Films of Losartan Potassium



Address:   1Ultra College of Pharmacy, Madhurai-20 2Anuradha College of Pharmacy, Chikhli.
DOI No: Not Available

ABSTRACT:
Besides acting as platforms for sustained release dosage forms, bioadhesive polymers can themselves exert some control over the rate and amount of drug release and thus contribute to the therapeutic efficacy of bioadhesive drug delivery system. The buccal route has been particularly popular among medical staff and patients alike. The mucosa is relatively permeable with a rich blood supply. The oral transmucosal drug delivery bypasses liver and avoids pre-systemic elimination in the GI tract and liver. The buccal mucoadhesive film using losartan potassium as drug and HPMC K (15M), Eudragit RS 100, Eudragit RL 100, SCMC and ethyl cellulose as polymer has prepared. The prepared buccal film from various batches was subjected to evaluation test. The bioadhesive strength of formulation F7 was higher (i.e.12.10 gm), due to higher concentration of SCMC among all the formulation SCMC having higher mucoadhesive property and less in F8 (i.e.7.48gm). The force required to break the film strip is more in formulation F1 containing HPMC 4:0 ratio, because of good cross-linking with drug molecules. The maximum drug release was shown by formulation F7 due to higher concentration of SCMC compared to other formulation it having higher drug release values due to swelling property. The lower drug release was shown by formulation F8 (73.97%) due to ethyl cellulose which is water insoluble. It was concluded that, HPMC and SCMC in equal concentration has good bioadhesive properties and released drug in sustained manner, hence best polymer for buccal drug delivery system.
KEYWORDS:
Buccal film, Bioadhesive, Tensile strength and Sustained release
Cite:
Not Available
[View HTML]     



Visitor's No. :   173287