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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   2

Issue No. :  4

Year :  2009

Pages :   

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Formulation, Characterization and in vitro Evaluation of Methotrexate Solid Lipid Nanoparticles



Address:   1Department of Pharmaceutics, K.L.E. Society’s College of Pharmacy, Hubli, India 2Department of Pharmaceutics, Al-Ameen College of Pharmacy, Bangalore, India 3Department of Chemistry, Karnataka University, Dharwad, India
DOI No: Not Available

ABSTRACT:
Solid lipid nanoparticles (SLNs) of methotrexate were produced by microemulsion method in an acidic aqueous system. The SLNs were composed of low melting fatty acid (glyceryl monostearate), surfactants (Egg lecithin and tween 80) and water. All the formulations were subjected to particle size analysis, zeta potential, drug entrapment efficiency and in vitro release studies. The SLNs formed were in nano-size range with maximum entrapment efficiency. Formulation with 253 nm in particle size and 85.12% of drug entrapment was subjected to scanning electron microscopy (SEM) for surface mophology, differential scanning calorimetry (DSC) for thermal analysis and short term stability studies. SEM confirms that the SLNs are circular in shape. The drug release behavior from SLN suspension exhibited biphasic pattern with an initial burst and prolonged release over 24 h.
KEYWORDS:
Solid lipid nanoparticles (SLNs) • Methotrexate (MTx) • Particle size analysis • Entrapment efficiency • In vitro release study
Cite:
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