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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   2

Issue No. :  4

Year :  2009

Pages :   

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Simultaneous Estimation of Montelukast Sodium and Levocetirizine Hydrochloride from Tablet Dosage Form



Address:   Adhiparasakthi College of pharmacy, Melmaruvathur-603 319, Tamilnadu.
DOI No: Not Available

ABSTRACT:
Three simple, accurate, economical and reproducible UV-Spectrophotometric methods for simultaneous estimation of Montelukast sodium (MK) and Levocetirizine hydrochloride (LC) from combined tablet dosage form have been developed and validated. First method uses absorbance correction principle using 287 and 232 nm, in which at 287nm LC has no absorbance. Second method uses multi wavelength, the wavelengths selected for estimation of MK were 232.2 and 229 nm where LC shows same absorbance. A third wavelength, 232 nm was selected for estimation of LC by applying absorbance correction principle. Third method was developed making use of first order derivative spectrophotometry 231.1 nm (Zero crossing point for LC) is utilized for estimation of MK and 216.5 nm (zero crossing point for MK) for estimation of LC.
KEYWORDS:
Absorbance correction method, first derivative spectrophotometry, multi wavelength spectrophotometry, montelukast sodium, levocetirizine hydrochloride.
Cite:
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