Journal :   Research Journal of Pharmacy and Technology

Volume No. :   2

Issue No. :  4

Year :  2009

Pages :   882-883

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Comparative Studies of Release of Ambroxol Hydrochloride from It’s Gum Based Matrices



Address:   Maushumi Kulkarni*, Kiran Bhise, Rashmi Tambe, Aney Joice and Parvez Shaikh
M.C.E. Society’s Allana College of Pharmacy 2390 KB Hidayatullah Road, Azam campus Camp, Pune 411001
*Corresponding Author
DOI No:

ABSTRACT:
The purpose of this research was to formulate matrices of Ambroxol hydrochloride with natural gums like Xanthan gum and ?- Carrageenan gum and their combinations in different ratios to develop a sustained release dosage form. Various parameters were evaluated such as their physical tests like hardness, thickness, friability. A comparative study was done on the release from various gum matrices. The matrix swelling was studied in pH 6.8 phosphate buffer. Xanthan gum, ?-Carrageenan and guar gum retarded the drug’s release when used individually. It can thus be concluded from the studies that natural gums can be effectively used for oral sustained release dosage form.
KEYWORDS:
sustained release, gums, swelling, matrices.
Cite:
Maushumi Kulkarni, Kiran Bhise, Rashmi Tambe, Aney Joice, Parvez Shaikh. Comparative Studies of Release of Ambroxol Hydrochloride from It’s Gum Based Matrices. Research J. Pharm. and Tech.2 (4): Oct.-Dec. 2009; Page 882-883.
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