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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   2

Issue No. :  4

Year :  2009

Pages :   880-881

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Spectrophotometric Determination of Quetiapine Fumarate in Bulk and Dosage Form

Address:   R Xavier Arulappa1*, M Sundarapandian2, S Venkataraman1, M Boopathi2 and Manish Kauraw1
1Department of Pharmaceutical Chemistry, 2Department of Pharmaceutical Analysis, K.M.College of Pharmacy, Uthangudi, Madurai -625 107. (TN). India.
*Corresponding Author

A simple, rapid, economical and sensitive visible spectrophotometric method for the estimation of Quetiapine fumarate has been developed based on the formation of ion-pair of Quetiapine fumarate with dye bromocresol green in acidic medium, which was extracted into chloroform. It has absorption maxima at 415nm. Beer’s law limit was found to be 5-25mcg/ml. The molar absorptivity was found to be 4.5x104(mole-1cm-1) and sandell’s sensitivity was 0.01949 (µg/cm2/0.001 absorbance unit). The correlation coefficient (r) was found to be 0.9999. The limit of detection (LOD) and limit of quantification (LOQ) was found to be 0.29 and 0.88 mcg/ml respectively of Quetiapine fumarate. The result of estimation in marketed formulations were found to be 97.44±0.3286 and 96.68±0.07854. The proposed method was applied successfully for the determination of Quetiapine fumarate in tablets with average recovery of 98.83±0.2738 and 98.98±0.3535. The method was then validated statistically as per ICH guidelines, which yielded good results concerning range, linearity, precision and accuracy.
Quetiapine fumarate, Bromo cresol green, Specrophotometry.
R Xavier Arulappa, M Sundarapandian, S Venkataraman, M Boopathi, Manish Kauraw. Spectrophotometric Determination of Quetiapine Fumarate in Bulk and Dosage Form. Research J. Pharm. and Tech.2 (4): Oct.-Dec. 2009; Page 880-881.
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