Journal :   Research Journal of Pharmacy and Technology

Volume No. :   2

Issue No. :  4

Year :  2009

Pages :   874-875

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Direct Spectrophotometeric Determination of Metformin Hydrochloride in Pure Form and in Pharmaceutical Formulations



Address:   PM Patil, MA Phanse, VL Gaikwad and PD Chaudhari
Modern College of Pharmacy, Nigdi, Pune - 44.
*Corresponding Author
DOI No:

ABSTRACT:
A new simple, sensitive spectrophotometric method in ultraviolet region has been developed for the determination of Metformin hydrochloride in bulk and dosage form. Metformin hydrochloride was shown maximum absorbance at 232 nm with apparent molar absorptivity of 1.0781×10 4l/mol.cm. Beer’s law was obeyed in the concentration range of 10 to 50 ug/ml. Results of analysis were validated statistically and by recovery studies. The developed method was found to be sensitive, accurate, precise and reproducible and can be used for the routine quality control analysis of metformin hydrochloride.
KEYWORDS:
Metformin hydrochloride, spectrophotometric, Assay, Recovery.
Cite:
PM Patil, MA Phanse, VL Gaikwad, PD Chaudhari. Direct Spectrophotometeric Determination of Metformin Hydrochloride in Pure Form and in Pharmaceutical Formulations. Research J. Pharm. and Tech.2 (4): Oct.-Dec. 2009; Page 874-875.
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