Journal :   Research Journal of Pharmacy and Technology

Volume No. :   2

Issue No. :  4

Year :  2009

Pages :   862-864

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Design and Dissolution Study of Colon Specific Drug Delivery System of Tinidazole



Address:   Mukund G Tawar* and PD Chaudhari
Pad. Dr D. Y. Patil Institute of Pharmaceutical Science and Research, Pimpri, Pune-411018.
*Corresponding Author
DOI No:

ABSTRACT:
A novel, colon-targeted delivery system, which uses lactulose, was investigated in this study. Lactulose is not absorbed in the upper GI tract, but degraded to organic acids by enterobacteria in the lower gastrointestinal tract, especially the colon. A CODESTM consists of three components: a core containing lactulose and the drug, an inner acid-soluble material layer, and an outer layer of an enterosoluble material. A CODESTM containing Tinidazole shown protections against pH 1.2 and pH 6.8 upto six hour study. Formulation shown release at pH 5.0. The results of this study show that lactulose can act as a trigger for drug release in the colon, utilizing the action of enterobacteria.
KEYWORDS:
Oral drug delivery; Colon targeting; Lactulose; Tinidazole.
Cite:
Mukund G Tawar, PD Chaudhari. Design and Dissolution Study of Colon Specific Drug Delivery System of Tinidazole. Research J. Pharm. and Tech.2 (4): Oct.-Dec. 2009; Page 862-864.
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