Journal :   Research Journal of Pharmacy and Technology

Volume No. :   2

Issue No. :  4

Year :  2009

Pages :   842-845

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Effect of Concentration of Gellan Gum and Calcium Chloride Solution on Entrapment Efficiency and Drug Release from Calcium Gellan Beads.



Address:   Patil SV*, Lade PD, Janugade BU, Babar SA and Ghewade YB
Department of Pharmaceutics, Shree Santkrupa College of Pharmacy, A/P Ghogaon, Tal. Karad, Dist. Satara. Maharashtra, 415111
*Corresponding Author
DOI No:

ABSTRACT:
Gellan gum has wide variety of applications, mainly concentrated in ophthalmic drug delivery and oral sustained release preparations. Due to the characteristic property of cation induced gelation, it has been widely used in the formulation at in situ gelling ophthalmic preparations. The objective of this study was to evaluate concentration dependant effect of gellan gum and calcium chloride solution on entrapment efficiency and drug release of diclofenac sodium through calcium-gellan beads by ionotropic gelation. Prepared beads were evaluated for percentage yield, percentage entrapment efficiency and drug release. It was found that as concentration of gellan gum increases entrapment efficiency increases and as concentration of calcium chloride increases entrapment efficiency decreases. Also as concentration of gellan gum increases drug release decreases and as concentration of calcium increases drug release increases.
KEYWORDS:
Calcium-gellan beads, Deacetylated gellan gum, Ionotropic gelation.
Cite:
Patil SV, Lade PD, Janugade BU, Babar SA, Ghewade YB. Effect of Concentration of Gellan Gum and Calcium Chloride Solution on Entrapment Efficiency and Drug Release from Calcium Gellan Beads. Research J. Pharm. and Tech.2 (4): Oct.-Dec. 2009; Page 842-845.
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