Journal :   Research Journal of Pharmacy and Technology

Volume No. :   2

Issue No. :  3

Year :  2009

Pages :   603-604

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Absorption Ratio Method for Simultaneous Estimation of Haloperidol and Trihexyphenidyl in Tablet



Address:   SP Wate and AA Borkar*
Sharad Pawar College of Pharmacy, Wanadongri, Hingna Road, Nagpur – 441 110
*Corresponding Author
DOI No:

ABSTRACT:
A simple, accurate, economical and reproducible procedure for simultaneous estimation of haloperidol (HP) and trihexyphenidyl (THP) in their tablet dosage form is described. The method involves absorbance measurement at 218.8 nm (isobestic point) and 245.0 nm (?max of haloperidol), in methanol and 0.1N HCl (90:10). Both the drugs obey Beer Lambert’s law in the concentration range of 2.5-12.5 µg/ml (HP) and 1.0-5.0 µg/ml (THP). The results of analysis have been validated statistically and by recovery studies.
KEYWORDS:
Haloperidol, Trihexyphenidyl, Validation.
Cite:
SP Wate, AA Borkar. Absorption Ratio Method for Simultaneous Estimation of Haloperidol and Trihexyphenidyl in Tablet. Research J. Pharm. and Tech.2 (3): July-Sept. 2009,;Page 603-604.
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