Journal :   Research Journal of Pharmacy and Technology

Volume No. :   2

Issue No. :  3

Year :  2009

Pages :   559-562

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Preparation and Evaluation of Metformin Hydrochloride Microcapsules



Address:   UD Shivhare*, V Darakh, VB Mathur, KP Bhusari and MD Godbole
*Sharad Pawar College of Pharmacy, Wanadongri, Hingna Road, Nagpur-441 110 *Corresponding Author
DOI No:

ABSTRACT:
Metformin hydrochloride, an orally administered drug used to lower blood glucose level in patients with non-insulin dependent diabetes mellitus (NIDDM). Its plasma half-life is relatively short and requires frequent dosing. With this view, metformin hydrochloride microcapsules were prepared using hydrophobic polymers i.e. Eudragit S100, ethylcellulose, cellulose acetate by o/o solvent evaporation technique. Different batches of microcapsules were prepared by altering the drug: polymer ratio. Best optimized formula was evaluated for its drug polymer interaction by IR spectra, X-ray diffraction for any polymorphic changes. Scanning electron microscopy indicated that microcapsules prepared were discrete spherical and covered with continuous coating.
KEYWORDS:
Preparation and Evaluation of Metformin Hydrochloride Microcapsules.
Cite:
UD Shivhare, V Darakh, VB Mathur, KP Bhusari, MD Godbole. Preparation and Evaluation of Metformin Hydrochloride Microcapsules. Research J. Pharm. and Tech.2 (3): July-Sept. 2009,;Page 559-562.
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