Journal :   Research Journal of Pharmacy and Technology

Volume No. :   2

Issue No. :  3

Year :  2009

Pages :   552-555

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Enhanced Skin Permeation of Glimepiride by Β -Cyclodextrin and Iontophoresis



Address:   Ashish Jain1*, Satish Nayak1, Bijaya Ghosh2, Rajesh S Jadon1 and Virendra Gajbhiye1
1Bansal College of Pharmacy, Kokta, Anand Nagar, Bhopal-462021, M.P., India.
2Department of Pharmaceutical Technology, K.L.E. Society’s college of Pharmacy, P.B No. 1062, II block, Rajajinagar, Bangalore-560010, India.
*Corresponding Author
DOI No:

ABSTRACT:
Enhanced skin permeation of glimepiride by iontophoresis across the pigskin was investigated. The experiment was carried out using cathodal iontophoresis (current density 0.5 mA cm-2) along with the passive controls. At all time points iontophoresis considerably increased the permeation rate compared to passive controls. Glimepiride is one of the third generation sulfonylureas used for treatment of type 2 diabetes. Poor aqueous solubility of the drug leads to irreproducible clinical response or therapeutic failure in some cases due to subtherapeutic plasma drug levels. Consequently, the rationale of this study was to improve the biological performance of this drug through enhancing its solubility and permeation rate by help of ß- cyclodextrin (ß-CyD) and iontophoresis.
KEYWORDS:
Glimepiride; Iontophoresis; β- cyclodextrin; Pigskin.
Cite:
Ashish Jain, Satish Nayak, Bijaya Ghosh, Rajesh S Jadon, Virendra Gajbhiye. Enhanced Skin Permeation of Glimepiride by Β -Cyclodextrin and Iontophoresis. Research J. Pharm. and Tech.2 (3): July-Sept. 2009,;Page 552-555.
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