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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   2

Issue No. :  3

Year :  2009

Pages :   544-547

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Antinociceptive Effect of Abutilon indicum Linn Leaf extract

Address:   Balamurugan Gunasekaran* and P Muralidharan
Department of Pharmacology, C. L. Baid Metha College of Pharmacy, Jyothi Nagar, Thoraipakkam, Chennai-600 097, Tamil Nadu, India.
*Corresponding Author

Abutilon indicum Linn (Sweet) (Malvaceae) leaves were extracted with water and evaluated for its antinociceptive effects by employing various models such as acetic acid-induced writhing test, tail immersion test, hotplate method and formalin-induced nociceptive test. The extract at 200 and 400 mg / kg concentration significantly (p<0.01) reduced the number of writhes produced by acetic acid (0.6 %) and significantly increased the reaction time in thermal models such as hot water tail immersion, hot plate method and formalin-induced test in a dose dependent manner (p<0.01). Morphine (7.5 mg / kg) and Indomethacin (10 mg /kg) were employed as the standard drugs for comparison. The results of the present study revealed that the aqueous extract of leaves of Abutilon indicum exhibits a potential analgesic effect, which may be mediated by both central and peripheral mechanisms.
Abutilon indicum, writhing test, hot water tail immersion, hot plate, formalin test, nociception.
Balamurugan Gunasekaran, P Muralidharan. Antinociceptive Effect of Abutilon indicum Linn Leaf extract. Research J. Pharm. and Tech.2 (3): July-Sept. 2009,;Page 544-547.
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