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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   2

Issue No. :  3

Year :  2009

Pages :   

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Eco-Friendly Synthesis and Biological Evaluation of Some Novel N-Substituted Piperazinyl Fluoro Quinolone Derivatives



Address:   Mother Theresa Post Graduate and Research Institute of Health Sciences, (A Govt. of Puducherry Institution), Indira Nagar, Gorimedu, Puducherry – 6.
DOI No: Not Available

ABSTRACT:
A series of novel N-substituted piperazinyl fluoro quinolones were synthesized under microwave technology. In the SAR study the aryl substituent’s on the piperazine nitrogen were found to play an important role for the Anti-HIV and cytotoxic activity. Four compounds were synthesized through modifying the N4-hydrogen of the piperazine in fluoroquinol ones with phthalimide. The purity of the synthesized compounds were ascertained by TLC and melting point determination. The structures of the synthesized compounds were screened for their Anti-HIV and invitro cytotoxic activity.
KEYWORDS:
Thalidomide , Norfloxacin, Ciprofloxacin, Sparfloxacin , Gatifloxacin , Phthalimide, Microwave assisted organic synthesis
Cite:
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