Journal :   Research Journal of Pharmacy and Technology

Volume No. :   2

Issue No. :  3

Year :  2009

Pages :   531-533

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Simultaneous Estimation of Ofloxacin and Satranidazole in Bulk and Dosage form by Ratio Spectra Derivative Spectroscopy



Address:   Shashikant R Pattan, Syed N Lateef, Prakash N Kendre, Nachiket S Dighe and Rahul K Godge*
Pravara Rural College of Pharmacy, Pravaranagar, Dist. Ahemadnagar (MS), India
*Corresponding Author
DOI No:

ABSTRACT:
A new sensitive, simple, rapid and precise method for simultaneous estimation of Ofloxacin and Satranidazole in bulk and combined tablet dosage form has been developed. The method is based on ratio derivative Spectrophotometry. The amplitude in first derivative of the ratio spectra at 300 nm and 222 nm (minima) were selected for Ofloxacin and Satranidazole respectively. The concentration range for Ofloxacin and Satranidazole chosen was 2-20 µg/ml and 3-30 µg/ml respectively. The method showed good linearity, accuracy and reproducibility. Results of analysis validated statistically and by recovery studies.
KEYWORDS:
Ofloxacin, Satranidazole, UV- spectrometry, Ratio derivative method.
Cite:
Shashikant R Pattan, Syed N Lateef, Prakash N Kendre, Nachiket S Dighe, Rahul K Godge. Simultaneous Estimation of Ofloxacin and Satranidazole in Bulk and Dosage form by Ratio Spectra Derivative Spectroscopy. Research J. Pharm. and Tech.2 (3): July-Sept. 2009,;Page 531-533.
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