Journal :   Research Journal of Pharmacy and Technology

Volume No. :   2

Issue No. :  3

Year :  2009

Pages :   513-516

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Formulation Design, Preparation of Losartan Potassium Microspheres by W/O Emulsion Solvent Evaporation Method and It’s In Vitro Characterization



Address:   Rout Prasant Kumar*1, Ghosh Amitava2, Nayak Udaya Kumar3 and Nayak Bhabani Shankar1
1Department of Pharmaceutics, Faculty of Pharmacy, Jeypore College of Pharmacy, Rondapalli, Jeypore – 764002, Koraput, Orissa, India.
2Himalayam Pharmacy Institute, Majitar, Rangpo, East Sikkim – India,
3R and D Officer, R and D Unit, Glenmark Pvt. Ltd., Navi Mumbai, India.
*Corresponding Author
DOI No:

ABSTRACT:
Present investigation describes preparation of microspheres prepared by W/O emulsion solvent evaporation method followed by in vitro characterization statistically. Microspheres containing Losartan potassium were prepared by solvent evaporation method by using sodium alginate and Acycoat E30D as rate controlling polymer. The microspheres were found to be discrete, spherical with free flowing properties. The morphology, particle size distribution, total entrapment of Losartan potassium into the micro particles and their release profiles were investigated. The morphology was investigated by Scanning Electron Microscopy. The mean geometric particle size of the microspheres prepared by W/O emulsion solvent evaporation method was found in a range of 126-150 µm respectively. The drug entrapment efficiency of all the formulations was found to be more than 80 %. The drug carrier interactions were investigated in solid state by FT-IR spectroscopy and HPLC study. In vitro drug release rate for microspheres (F12) was found to be sustained over 8 hours obeying zero order kinetic with good entrapment efficiency and flow properties. Hence it can be concluded that the formulation F12 has potential to deliver Losartan potassium in a controlled manner over other formulations and can be adopted for a successful delivery of Losartan potassium for oral use for safe management of hypertension. All data are verified as statistically significant by using one way ANOVA at 5 % level of significance (p < 0.05).
KEYWORDS:
Losartan potassium, Microspheres, W/O emulsion solvent evaporation, Entrapment efficiency.
Cite:
Rout Prasant Kumar, Ghosh Amitava, Nayak Udaya Kumar, Nayak Bhabani Shankar. Formulation Design, Preparation of Losartan Potassium Microspheres by W/O Emulsion Solvent Evaporation Method and It’s In Vitro Characterization. Research J. Pharm. and Tech.2 (3): July-Sept. 2009,;Page 513-516.
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