Journal :   Research Journal of Pharmacy and Technology

Volume No. :   2

Issue No. :  3

Year :  2009

Pages :   495-497

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Validated Spectroscopic Method for Estimation of Sumatriptan succinate in Pure and from Tablet Formulation



Address:   A. Elphine Prabahar1*, R. Kalaichelvi2, B. Thangabalan1 R. Karthikeyan1 , Ch. Prabhakar3 and P. Vijayaraj Kumar4
1Department of Pharmacy, Donbosco PG College, Vetticherukuru Mandal, Guntur 522 017, India
2K.C.Reddy Institute of Pharmaceutical Sciences, Jangamguntla Palem, Medikonduru Mandal, Guntur 522 348, India
3Nova College of Pharmacy, Jangareddygudem, W. G. Dist. (AP), India.
4Bharat Institute of Pharmacy, Mangalpally Village, Ibrahimpatnam. RR Dist.-501506, India.
*Corresponding Author
DOI No:

ABSTRACT:
Sumatriptan succinate (sumatriptan) is a 5HT1D-Serotonin receptor agonist which is used to treat migraine and it has good vasoconstrictor properties. Only HPLC methods are available for analysis of the same but they are expensive. There is no UV method is available. Here we have developed a new, precise and simple UV spectrophotometric method for estimation of sumatriptan from tablet formulation. The drug obeyed the Beer’s law and showed good correlation. It showed absorption maxima at 220 nm; double distlled water. The linearity was observed between 1 – 12 mcg/ml. The results of analysis were validated by recovery studies. The recovery was more than 99%. The method was found to be simple, accurate, precise, economical and robust.
KEYWORDS:
Sumatriptan, UV–Vis Spectrophotometry, Migraine, Validation.
Cite:
A. Elphine Prabahar, R. Kalaichelvi, B. Thangabalan, R. Karthikeyan, Ch. Prabhakar, P. Vijayaraj Kumar. Validated Spectroscopic Method for Estimation of Sumatriptan succinate in Pure and from Tablet Formulation. Research J. Pharm. and Tech.2 (3): July-Sept. 2009,;Page 495-497.
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