Journal :   Research Journal of Pharmacy and Technology

Volume No. :   2

Issue No. :  3

Year :  2009

Pages :   470-473

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Development and Evaluation of Tramadol Hydrochloride Sustained Release Tablet



Address:   Mukund G Tawar 1*, Pawar M D2 and P D Chaudhari1
1Pad. Dr D. Y. Patil Institute of Pharmaceutical Science and Research, Pune-411 018
2Micro Laboratories Ltd. Bangalore, Karnataka
*Corresponding Author
DOI No:

ABSTRACT:
The objective of this study was to develop competitive sustained release tablets of Tramadol Hydrochloride which releases the drug in a sustained manner, by using different polymers and study on there effect on release pattern. The effect of HPMC K100M, HPC, ethyl cellulose, xanthan gum, sodium CMC, ckarbopol 934P, hydrogenated castor oil, with tramadol HCl in ratio (1:1) on release rate was studied. SR tablet of tramadol HCl (dose 100mg) were prepared by wet granulation, dry granulation, melt granulation and direct compression technique. In-vitro dissolution studies performed using USP apparatus type I in the phosphate buffer media (pH 6.8) upto 12 h. For 12 h release, the ratio of drug with alone carbopol 934P (1:0.8) was found to be best suited for modulating the delivery of highly water soluble drug tramadol HCl.
KEYWORDS:
Tramadol HCl, polymers, non-fickian release, sustained release.
Cite:
Mukund G Tawar , Pawar M D, P D Chaudhari. Development and Evaluation of Tramadol Hydrochloride Sustained Release Tablet. Research J. Pharm. and Tech.2 (3): July-Sept. 2009,;Page 470-473.
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