List of Refereed Journals published by UGC, New Delhi on 28-03-2017-- AJRC (Sr. No.-1025); AJM (Sr. No.-2497); RJET (Sr. No.-7220); RJPP (Sr. No.- 7232): RJPPD (Sr. No.- 7234); RJPT (Sr. No.-7235) (19-Apr-2017)        | List of Refereed Journals published by UGC, New Delhi on 11-01-2017-- Research Journal of Pharmacy and Technology (Sr. No.-275); Asian Journal of Management (Sr. No.-3986); Asian Journal of Research in Chemistry (Sr. No.-4008); Research Journal of Engineering and Technology (Sr. No.-31787); Research (22-Jan-2017)        |

Journal :   Research Journal of Pharmacy and Technology

Volume No. :   2

Issue No. :  3

Year :  2009

Pages :   

ISSN Print :  0974-3618

ISSN Online :  0974-360X


Registration

Allready Registrered
Click to Login

Preparation and Characterization of Bi-Layer Matrix Tablets of Amoxicillin Tri-Hydrate



Address:   1Aurobindo pharma limited, Research and development, Bachupally, Hyderabad, AP, India. 2Centre For Biotechnology, Institute of Science and Technology, JNTU, Kukatpally, Hyderabad, AP, India 3Nalanda College of Pharmacy, Charlapally, Nalgonda, AP, India
DOI No: Not Available

ABSTRACT:
Amoxicillin bi layer matrix tablets were prepared using cellulose acetate (CA) and cellulose acetate butyrate (CAB) as matrix polymers for the extended release of amoxicillin. The matrix tablets consists of one immediate release layer which release and one sustained release layer which release the drug for a prolonged period of time. The matrix tablets were prepared by direct compression method. The prepared matrix tablets were characterized for the physical properties, drug content, differential scanning calorimetry (DSC) and in vitro dissolution studies. The prepared matrix tablets were kept for accelerated stability study as per ICH guidelines for about 3 months. The prepared bi layer matrix tablets were showing good physical properties. The initial rapid drug release from the bi layer matrix tablets was observed. The drug release was extended up to 16 hours. Differential scanning calorimetric thermographs shows the stable character of Amoxicillin tri-hydrate. The release kinetics study revealed that the prepared matrix tablets were best fitted to the first order in all the formulations. All the formulations were best fitted to Higuchi model indicated that the drug release was diffusion controlled. The release kinetics study revealed that the prepared bi-layer matrix tablets were best fitted to the first order. All the formulations were best fitted to Higuchi model indicated that the drug release was diffusion controlled. The prepared matrix tablets were having high commercial application.
KEYWORDS:
Amoxicillin tri-hydrate; cellulose polymers; bi layer matrix tablets; controlled release; stability.
Cite:
Not Available
[View HTML]     



Visitor's No. :   173220