Journal :   Research Journal of Pharmacy and Technology

Volume No. :   2

Issue No. :  3

Year :  2009

Pages :   456-462

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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In Vitro and In Vivo Evaluation of the Chitosan Microparticulate Ocular Delivery System of Ketorolac Tromethamine

Address:   Anupama Chawla1and Munish Ahuja2
1Rajendra Institute of Science and Technology, Sirsa, India
2Dept. of Pharma. Sciences, Guru Jambheshwar University of Science and Tech., Hisar- 125 001, Haryana, India
*Corresponding Author

The microparticulate ocular delivery system for ketorolac tromethamine based on chitosan was prepared and characterized for particle size, morphology, entrapment efficiency, in vitro release and in vivo ocular anti-inflammatory activity. Chitosan microparticles of ketorolac tromethamine were prepared by modified emulsification ionic gelation method, using sodium tripolyphosphate as the ionic cross linking agent. Particle size and morphology was assessed using optical microscopy. In vitro release was determined using shaker method. In vivo ocular anti inflammatory activity was determined in prostaglandin E2-induced rabbit ocular inflammation model. The mean particle size and entrapment efficiency was found to decrease, while in vitro release was found to increase with decrease in the concentration of chitosan and sodium tripolyphosphate. The release of ketorolac tromethamine from prepared microparticles followed zero order kinetics. The inhibitory effect of ketorolac loaded microparticles against prostaglandin E2 – induced polymorphonuclear leukocyte migration was found to be slow and sustained. In conclusion, chitosan microparticulate ocular suspension of ketorolac tromethamine can be used for prolonging the precorneal residence and sustaining the drug release.
Chitosan, Ketorolac tromethamine, sodium tripolyphosphate,
Anupama Chawla, Munish Ahuja. In Vitro and In Vivo Evaluation of the Chitosan Microparticulate Ocular Delivery System of Ketorolac Tromethamine. Research J. Pharm. and Tech.2 (3): July-Sept. 2009,;Page 456-462.
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