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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   2

Issue No. :  3

Year :  2009

Pages :   

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Anti-Inflammatory Activity of Petroleum Ether Extract of Seeds of Ocimum Basilicum Linn



Address:   1Rajendra Institute of Technology and Sciences, 4th mile stone, Hisar Road, Sirsa- 125055 2Dept. of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Hisar- 125001.
DOI No: Not Available

ABSTRACT:
In the present study we have studied the effect of petroleum ether extract of seeds of the plant Ocimum basilicum Linn. on acute phase of inflammation induced by carrageenan and formalin. The chronic phase of inflammation was studied using cotton pellet granuloma technique. The increase in paw thickness was measured using digital vernier caliper after 1, 2, 3 and 4h of injection. Petroleum ether extract at dose of 400 mg/Kg significantly inhibited acute phase of inflammation induced by carrageenan and formalin. The decrease in the weight of granuloma was also found by the extract at dose of 400mg/kg. The study clearly shows that the petroleum ether extract of seeds of Ocimum basilicum Linn. possesses significant anti-inflammatory activity.
KEYWORDS:
Anti-inflammatory, carrageenan, formalin, granuloma.
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