Journal :   Research Journal of Pharmacy and Technology

Volume No. :   2

Issue No. :  2

Year :  2009

Pages :   405-408

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Antioxidant Activity of Fumaria Officinalis Linn. And Its Study on Ethanol Induced –Immunosupression



Address:   SJ Wasu* and BP Muley
Siddhivinayak College of Pharmacy, Pharmacology Department, Abhyankar ward, Warora, Dist- Chandrapur, Maharashtra State, India – 442 907.
*Corresponding Author
DOI No:

ABSTRACT:
In the present study, we investigated the antioxidant activity and ethanol-induced immunosupression study of alcoholic extract of Fumaria officinalis Linn. (FO). In this study the ethanol-treated (2 g/kg, 20% w/v, p.o., daily for four weeks) rats concurrently received either FO or a combination of vitamin E and C (each 100 mg/kg, p.o.) daily for the same period. The parameters like phagocytosis, total leukocyte count (TLC), humoral and cell-mediated immune responses, lipid peroxidation (LPO), reduced glutathione (GSH) content, superoxide dismutase (SOD) and catalase (CAT) activities were assessed. It was found that the chronic administration of ethanol decreased the humoral and cell-mediated immune response, phagocytosis, phagocytosis index, TLC, GSH, CAT and SOD activities and increased the LPO. These influences of ethanol were prevented by concurrent daily administration of FO and the effect was comparable with that of the combination of vitamin E and C.
KEYWORDS:
Fumaria officinalis, antioxidant activity and ethanol induced immunosupression.
Cite:
SJ Wasu, BP Muley. Antioxidant Activity of Fumaria Officinalis Linn. And Its Study on Ethanol Induced –Immunosupression. Research J. Pharm. and Tech.2(2): April.-June.2009,;Page 405-408.
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