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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   2

Issue No. :  2

Year :  2009

Pages :   

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Simultaneous Spectrophotometric Estimation of Nitazoxanide and Ofloxacin in Combained Tablet Dosage Form



Address:   1Jeypore College of Pharmacy, Jeypore, Koraput, Orissa, India-764002. 2School of Pharmacy, Devi Ahilya Vishwavidyalaya, Takshasila campus, Khandwa Road, Indore, (M P) 452017.
DOI No: Not Available

ABSTRACT:
Two simple, rapid, accurate and economical analytical methods have been developed for the simultaneous estimation of Nitazoxanide and Ofloxacin in combined tablet dosage form. First method is based on the determination of Q-value and Second method is based on simultaneous equation method. Nitazoxanide has absorbance maxima at 345.6 nm and Ofloxacin has absorbance maxima at 294.4 nm in acetonitrile and phosphate buffer (PH 2.5) ARgrade. The absorption ratio (Q-value) was determined at 320.6 nm (Iso-absorptivity point) and 345.6 nm (λmax of Nitazoxanide).Both the drugs obey Beer’s law in the concentration ranges employed for these methods. Both the methods were found to be simple, rapid, and accurate and can be adopted in routine analysis of drugs in formulations. The accuracy and reproducibility of the proposed method was statistically validated by recovery studies.
KEYWORDS:
Absorption ratio, Simultaneous equation, Overlain spectra, Recovery studies.
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