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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   2

Issue No. :  2

Year :  2009

Pages :   

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Preparation and Evaluation of Rifabutin Loaded Polymeric Microspheres



Address:   Dept. of Biopharmaceutics, Govt. College of Pharmacy, Karad – 415 124, Dist: Satara, MS, India.
DOI No: Not Available

ABSTRACT:
Present study was designed to investigate the effect of various processing parameters on the physical characteristics of the rifabutin (RFB) microspheres prepared by emulsion solvent diffusion using EC and EC/HPMC polymers. XRD and DSC studies were performed to determine its crystallinity. At the end of 8 hrs, more than 90 % of the drug was released by EC/HPMC microspheres; however from EC microspheres only 88 % of the drug was released after of 12 hrs. Particle size and spherical shape of the microspheres were confirmed by SEM photomicrographs. Microspheres were found to be stable and non-hygroscopic at accelerated conditions of temperature and humidity.
KEYWORDS:
Rifabutin (RFB), emulsion solvent diffusion, ethyl cellulose, HPMC.
Cite:
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