List of Refereed Journals published by UGC, New Delhi on 28-03-2017-- AJRC (Sr. No.-1025); AJM (Sr. No.-2497); RJET (Sr. No.-7220); RJPP (Sr. No.- 7232): RJPPD (Sr. No.- 7234); RJPT (Sr. No.-7235) (19-Apr-2017)        | List of Refereed Journals published by UGC, New Delhi on 11-01-2017-- Research Journal of Pharmacy and Technology (Sr. No.-275); Asian Journal of Management (Sr. No.-3986); Asian Journal of Research in Chemistry (Sr. No.-4008); Research Journal of Engineering and Technology (Sr. No.-31787); Research (22-Jan-2017)        |

Journal :   Research Journal of Pharmacy and Technology

Volume No. :   2

Issue No. :  2

Year :  2009

Pages :   

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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The Estimation of Gefitinib in Tablet Dosage Forms by RP-HPLC

Address:   ¶Department of Pharmaceutical Chemistry, Sree Chaitanya Institute of Pharmaceutical Sciences, LMD.Colony, Karimnagar-505527.AP. *Department of Pharmaceutical Chemistry, Sultan-Ul-Uloom College of Pharmacy, Mount Pleasant, Road# 3, Banjara Hills, Hyderaba
DOI No: Not Available

A simple, precise, rapid and accurate reverse phase HPLC method developed for the estimation of Gefitinib in tablet dosage form. An Hypersil BDS RP C18, 250x4.6 mm, 5 μm partical size, with mobile phase consisting of 0.02 M Dipotassium Hydrogen ortho phosphate and Methanol in the ratio of 10:90 v/v was used. The flow rate was 1.0 ml/min and the effluents were monitored at 246 nm. The retention time was 3.7 min. The detector response was linear in the concentration of 25-300μg/ml. The respective linear regression equation being Y= 94342.26x+77672.7. The limit of detection and limit of quantification was 0.125μg/ml and 0.15μg/ml respectively. The percentage assay of Gefitinib was 99.5 %. The method was validated by determining its accuracy, precision and system suitability. The results of the study showed that the proposed RP-HPLC method is simple, rapid, precise and accurate, which is useful for the routine determination of Gefitinib in bulk drug and in its pharmaceutical dosage form.
Gefitinib, RP-HPLC, Estimation, and Tablets.
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