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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   2

Issue No. :  2

Year :  2009

Pages :   

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Superdisintegrants Effect on Three Model Drugs from Different BCS Classes



Address:   MAEER’s Maharashtra Institute of Pharmacy, Paud Road, Kothrud, Pune – 411 038.
DOI No: Not Available

ABSTRACT:
The proper choice of disintegrants or superdisintegrants and its consistency of performance are of critical importance to formulation development. Most of papers published on the choice of superdisintegrant show varying results. Hence, this paper aimed in reasoning the effect of superdisintegrant on various drugs with respect to their solubility characteristics or their BCS classification. For this purpose, superdisintegrants like Sodium Starch Glycolate [SSG], Crospovidone [CRP], Croscarmellose sodium [CCS], and Methacrylic copolymer with divinyl benzene i.e. Polyflash® P-544D (Doshion) were studied on individual formulation of Diclofenac free acid, Famotidine and Tramadol. It was found that the relationship between disintegration time is dependant on the type of system and in particular the solubility. characteristic of the entire system.
KEYWORDS:
Superdisintegrants, BCS class, solubility
Cite:
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