Journal :   Research Journal of Pharmacy and Technology

Volume No. :   2

Issue No. :  1

Year :  2009

Pages :   65-71

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Supercritical Fluid Technology in Pharmaceuticals: An overview

Address:   Tripti Jain1*, V Jain2, R Pandey2, SJ Daharwal2, SS Shukla2 and A Vyas2
1Rungta College of Pharmaceutical Sciences and Research, Bhilai, C.G., India
2Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur, C.G., India
*Corresponding Author

In the past five years research and process development activity has focused on utilizing supercritical carbon dioxide technology in processing fine chemicals, pharmaceutical intermediates and nutraceuticals. In addition to being a solvent for extraction and fractionation (purification) of organic compounds, carbon dioxide is increasingly being utilized as a medium for reactions, as a micronizing agent in rapid expansion in a supercritical solution process (RESS), as an anti-solvent for crystallization in gas anti-solvent process (GAS) and as a carrier solvent for coating and depositing materials onto or into a solid matrix. Carbon dioxide technology is one of fastest growing new process technologies being adopted by the food, pharmaceutical and nutraceutical industries. Supercritical fluid technology will allow developing products of standardized concentration of active ingredients, and will simultaneously produce nutraceutical and pharmaceutical products of much higher concentration (higher yields and purity) and quality (with less creation of artifacts), than possible by conventional chemical engineering unit operations, such as liquid and/ or gas phase reactions etc.
Supercritical Fluid Technology.
Tripti Jain, V Jain, R Pandey, SJ Daharwal, SS Shukla, A Vyas. Supercritical Fluid Technology in Pharmaceuticals: An overview. Research J. Pharm. and Tech. 2(1): Jan.-Mar. 2009; Page 65-71.
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