Journal :   Research Journal of Pharmacy and Technology

Volume No. :   2

Issue No. :  1

Year :  2009

Pages :   168-172

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Design, Development, Physicochemical and In Vitro Evaluation of Transdermal Patches Containing Verapamil Hydrochloride in Ethyl Cellulose - Povidone Matrices



Address:   Chakraborty Prithviraj*1, Dey Biplab K.2, Bahadur Sanjib3, Thakkar Suresh1 and Das Sudip1
1S.D. College of Pharmacy, Barnala, Punjab, PIN 148101
2Dept.of Pharmaceutics, Himalayan Pharmacy Institute, Majhitar, Rangpo, East Sikkim, PIN-737136
3Oriental College of Pharmacy, Thakral Nagar, Raisen Road, Bhopal 462021
*Corresponding Author
DOI No:

ABSTRACT:
An attempt has been made to develop transdermal patches of Verapamil HCI by using ethyl cellulose and polyvinyl pyrrolidoneK30 as polymer matrix, dibutyl phthalate as plasticiser and polyvinyl alcohol as backing membrane. The present study has revealed the designing and in vitro evaluation of transdermal patches containing verapamil hydrochloride in ethyl cellulose - povidone matrices. After preparation of patches several physicochemical properties were examined i.e. thickness, percent moisture content, percent moisture uptake, percent flatness, water vapour transmission rate, tensile strength and weight variation to satisfy the suitable criteria’s. In vitro skin permeation study was performed taking rat skin using modified Keshary -Chien diffusion cell. After the graphical examination conclusion was drawn that in formulation with higher concentration of hydrophobic polymer, patches releases drug extending 24hrs whereas with higher amount of hydrophilic polymer drug release occurred less than above. Drug- polymer interactions were studied by FTIR spectroscopy and surface morphologies of the films were investigated using SEM.
KEYWORDS:
Verapamil hydrochloride, Transdermal patch, Ethyl cellulose,
Cite:
Chakraborty Prithviraj, Dey Biplab K., Bahadur Sanjib, Thakkar Suresh, Das Sudip. Design, Development, Physicochemical and In Vitro Evaluation of Transdermal Patches Containing Verapamil Hydrochloride in Ethyl Cellulose - Povidone Matrices. Research J. Pharm. and Tech. 2(1): Jan.-Mar. 2009; Page 168-172.
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