Journal :   Research Journal of Pharmacy and Technology

Volume No. :   2

Issue No. :  1

Year :  2009

Pages :   110-113

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Improved Dissolution Characteristics of Lovastatin by Inclusion in -CD and Hp -CD



Address:   Ashok Malpani1*, S Appala Raju2 and SN Hiremath3
1K.C.T. College of Pharmacy, Gulbarga-585105,
2H.K.E.S. College of Pharmacy, Gulbarga- 585105
3P.R.E.Society’s, College of Pharmacy, Chincholi, Nashik-422101
*Corresponding Author
DOI No:

ABSTRACT:
Lovastatin is a hydrophobic molecule practically insoluble in aqueous media and exhibits an exceedingly slow intrinsic dissolution rate. In the present work inclusion complexes of lovastatin were prepared with the soluble complexing agents ?-CD and HP ?-CD. Phase solubility studies revealed the formation of 1:1 complex of AL type with a stability constant Kc Of 85.91 m-1 and 113.49 m-1 for ?-CD and HP ?-CD respectively in water. Interactions of the drug ?-CD and HP ?-CD in the solid state were studied using FTIR, DSC and X-ray powder diffraction studies. Preparation of kneading mixture of drug and HP?-CD increased both the aqueous solubility and the dissolution rate.
KEYWORDS:
Lovastatin, -CD and HP -CD, Inclusion, dissolution rate.
Cite:
Ashok Malpani, S Appala Raju, SN Hiremath. Improved Dissolution Characteristics of Lovastatin by Inclusion in -CD and Hp -CD. Research J. Pharm. and Tech. 2(1): Jan.-Mar. 2009; Page 110-113.
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