Journal :   Research Journal of Pharmacy and Technology

Volume No. :   2

Issue No. :  1

Year :  2009

Pages :   86-90

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Design and Evaluation of Terbutaline Sulphate Buccal Patch



Address:   Wani MS *1, Dehghan MH2, Mahendrakumar C3, Polshettiwar SA1 and Yadav VB4
1Dept. of Pharmaceutics, MAEER’s Maharashtra Institute of Pharmacy, MIT Campus, Paud Road, Kothrud, Pune 411 038.
2Dept. of Pharmaceutics, Y.B. Chavan College of Pharmacy, Dr. Rafiq Zakaria Campus, Aurangabad – 431001.
3Dept. of Pharmaceutics, St. Marry College of Pharmacy, St. Francis Street, Secunderabad.
4Dept. of Pharmaceutics, Govt. College of Pharmacy, Karad, Dist Satara.
*Corresponding Author
DOI No:

ABSTRACT:
Mucoadhesive patches for delivery of Terbutaline sulphate were prepared using hydroxyl propyl methyl cellulose K4M, hydroxyl ethyl cellulose and carbopol 934P. Glycerin was used as a plasticizer. Mucoadhesive strength, % Swelling, Surface pH, Film Thickness and Folding Endurance were determined for plain patches. The results showed Mucoadhesive strength of hydroxyl propyl methyl cellulose K4M plain and hydroxyl propyl methyl cellulose K4M combination polymeric patches were found to be greater than hydroxyl ethyl cellulose plain and hydroxyl ethyl cellulose combination polymeric patches. It was found that mucoadhesive strength increases with the increase in concentration of carbopol. Percent swelling of patches increased with time and with an increase in concentration of hydrophilic polymer. Incorporation of carbopol increase percent swelling. Percent swelling showed a direct relationship with mucoadhesive strength. The folding endurance of the polymeric patch was found to be 79 to 138. The surface pH of the film was found to be in region of the neutral pH. The mean film thickness of the buccal polymeric patches increases with an increase in the amount of polymer. Drug content uniformity values of Terbutaline sulphate buccal patch were observed to be between 100.18 % and 99.18% of the labeled amount. In-vitro release studies of Terbutaline sulphate buccal patches showed decrease in percent release with an increase in the amount of polymer. The buccal patches of Terbutaline sulphate were found to be stable at 75±5% RH and 45 ±2ºC when stored for 24 weeks.
KEYWORDS:
Buccal patches; terbutaline sulphate; mucoadhesive studies; percentage swelling, in-vitro release.
Cite:
Design and Evaluation of Terbutaline Sulphate Buccal PatchWani MS , Dehghan MH, Mahendrakumar C, Polshettiwar SA, Yadav VB. Research J. Pharm. and Tech. 2(1): Jan.-Mar. 2009; Page 86-90.
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