Journal :   Research Journal of Pharmacy and Technology

Volume No. :   1

Issue No. :  4

Year :  2008

Pages :   484-486

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Design and Evaluation of β-cyclodextrin Complexes of Meloxicam Tablet



Address:   Manivannan Rangasamy*, Ayyasamy Balasubramaniam and Sandeep Gummadevelly
Department of Pharmaceutics, J.K.K.M.M.R.F. College of Pharmacy, Komarapalayam, Pin: 638 183, Namakkal, Tamilnadu, India.
*Corresponding Author
DOI No:

ABSTRACT:
?-Cyclodextrin complexation of meloxicam was attempted to enhance the solubility features of the drug. This work was investigated the possibility of developing meloxicam tablets are allowing to get fast reproducible and complete drug disintegration by using ß-Cyclodextrin complexation. The tablets were prepared by direct compression technique and evaluated for thickness, uniformity of weight, content uniformity, hardness, friability, disintegration and in-vitro dissolution time. Stability study for the selected formulations was conducted for a period of one month at 25°C, 40°C and 60°C respectively and the formulations exhibited no alteration in the physical appearance or content of the tablet. The complex prepared by direct compression method was found to be yield very reliable and best results over that of the wet granulation method.
KEYWORDS:
Β-cyclodextrin, microcrystalline cellulose, croscarmellose sodium, meloxicam.
Cite:
Manivannan Rangasamy, Ayyasamy Balasubramaniam, Sandeep Gummadevelly. Design and Evaluation of β-cyclodextrin Complexes of Meloxicam Tablet. Research J. Pharm. and Tech. 1(4): Oct.-Dec. 2008;Page 484-486.
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