Journal :   Research Journal of Pharmacy and Technology

Volume No. :   1

Issue No. :  4

Year :  2008

Pages :   478-480

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Formulation and In-Vitro Evaluation of Mucoadhesive Buccal Tablets of Diltiazem Hydrochloride



Address:   R Manivannan1*, A Balasubramaniam1, DC Prem Anand1, G Sandeep1 and N Rajkumar2.
1Department of Pharmaceutics, J.K.K.M.M.R.F. College of Pharmacy, Komarapalayam, Pin: 638 183, Namakkal, Tamilnadu, India.
2Department of Pharmaceutics, University College of Pharmaceutical Sciences, Kakatiya University, Warangal – 506002, Andhra Pradesh, India.
*Corresponding Author
DOI No:

ABSTRACT:
Mucoadhesive buccal tablets of Diltiazem hydrochloride were prepared using carbopol-934, Sodium carboxy methyl cellulose (SCMC), Hydroxy propyl methyl cellulose (HPMC), sodium alginate and guar-gum as mucoadhesive polymers. Eight formulations were developed with varying concentrations of polymers. The carbopol-934 is used as a primary polymer because of its excellent mucoadhesive property and secondary polymers like HPMC, SCMC, sodium alginate and guar-gum were used. The effect of secondary polymer loading on drug release was studied. The formulations were tested for in-vitro drug release and in-vitro swelling studies. Formulation FA2 showed maximum release of 76.98% in 8hours. Formulation FC2 showed maximum swelling index of 3.7 after 8hours. Formulation FA2 follows zero order drug release. FTIR studies show no evidence on interaction between drug and polymers. The results indicate that suitable mucoadhesive buccal tablets with desired properties could be prepared.
KEYWORDS:
Buccal tablets, Diltiazem Hydrochloride, Formulation, Swelling and Evaluation.
Cite:
R Manivannan, A Balasubramaniam, DC Prem Anand, G Sandeep, N Rajkumar. Formulation and In-Vitro Evaluation of Mucoadhesive Buccal Tablets of Diltiazem Hydrochloride. Research J. Pharm. and Tech. 1(4): Oct.-Dec. 2008;Page 478-480.
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