Journal :   Research Journal of Pharmacy and Technology

Volume No. :   1

Issue No. :  4

Year :  2008

Pages :   469-471

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Simultaneous UV Spectrophotometric Method for the Estimation of Nitazoxanide and Ofloxacin in Combined Dosage Form



Address:   M. Senthilraja*
Dept. of Pharma. Analysis, J.K.K.Nataraja College of Pharmacy, Natarajapuram, NH-47, Salem Main Road, Komarapalayam- 638183, Tamilnadu, INDIA.
*Corresponding Author
DOI No:

ABSTRACT:
A simple, sensitive, rapid, accurate and precise simultaneous UV-spectrophotometric method was developed for the estimation of nitazoxanide and ofloxacin dosage form. Ratio of absorbance at two selected wavelengths, one of which an isoabsorbance point and being the ? max of the one of the two components. Ofloxacin has absorbance maxima at 300nm and nitazoxanide has absorbance maxima at 344nm in Ethanol. The isoabsorbance point of ofloxacin and nitazoxanide was found to be 347nm. Linearity was obtained in the concentration range of 2-25µg/ml for each nitazoxanide and ofloxacin Result of analysis have been validated statically and by recovery studies.
KEYWORDS:
Nitazoxanide; Ofloxacin; UV Spectrophotometer; Ethanol.
Cite:
M. Senthilraja. Simultaneous UV Spectrophotometric Method for the Estimation of Nitazoxanide and Ofloxacin in Combined Dosage Form. Research J. Pharm. and Tech. 1(4): Oct.-Dec. 2008; Page 469-471.
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