Journal :   Research Journal of Pharmacy and Technology

Volume No. :   1

Issue No. :  4

Year :  2008

Pages :   460-468

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Design and Evaluation of Ofloxacin Extended Release Ocular Inserts For Once a Day Therapy



Address:   Karthikeyan D*1, Bhowmick M1, Pandey VP2, Sengottuvelu S1, Sonkar S1, Gupta N1, Mohod V1 and Shivakumar T1
1Nandha College of Pharmacy, Erode-638052, Tamil Nadu, India.
2Department of Pharmacy, Faculty of Science and Technology, Annamalai University, Chitambaram, India
*Corresponding Author
DOI No:

ABSTRACT:
The aim of the study was to develop an extended release ocular insert for once a day therapy for the controlled delivery of ofloxacin and to evaluate its efficacy in vitro and in vivo. Reservoir type ocular inserts of ofloxacin were prepared by solvent casting method. Twelve formulations were developed, which differed in the ratio of polymers Eudragit RS 100 and Ethyl cellulose used for the preparation of the rate controlling membrane and polymer HPMC was used for the preparation of drug reservoir. When commercial semi-permeable membrane was used, the optimized formulation F10 was found to give best release with 97.14% at the end of 24 hours in concentration independent manner and when the same formulation was used to study release rate through excised goat cornea has shown release of 88.51% at the end of 24 hours in concentration independent manner. The above in vitro release studies revealed that the ocular inserts followed zero-order release kinetics. Higuchi’s plot and Peppa’s plot revealed that the mechanism of drug release involved in all the formulations was super case II transport diffusion. The optimized formulation F10 was applied in the cul-de-sac of albino rabbits and at adequate intervals (12th and 24th hr), the tear fluid and aqueous humor were collected and the drug concentration was determined by an HPLC method. The in-vitro and in-vivo studies revealed that good correlation exist between the two and the formulation F10 was capable of releasing the drug in concentration independent manner for the extended period of 24 hours and remained stable and intact at ambient conditions.
KEYWORDS:
Extended release, Excised goat cornea, Tear fluid, Aqueous humor.
Cite:
Karthikeyan D, Bhowmick M, Pandey VP, Sengottuvelu S, Sonkar S, Gupta N, Mohod V, Shivakumar T. Design and Evaluation of Ofloxacin Extended Release Ocular Inserts For Once a Day Therapy. Research J. Pharm. and Tech. 1(4): Oct.-Dec. 2008; Page 460-468.
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