Journal :   Research Journal of Pharmacy and Technology

Volume No. :   1

Issue No. :  4

Year :  2008

Pages :   433-436

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Design and Evaluation of Controlled Release Bhara Gum Microcapsules of Famotidine for Oral Use



Address:   Nayak Bhabani Shankar*1, Nayak Udaya Kumar2, Patro K Balakrishna2 and Rout Prasant Kumar1
1Jeypore College of Pharmacy, Rondapalli, Jeypore-764002, Koraput, Orissa, India 2Glenmark R and D Unit, Navi Mumbai, India
*Corresponding Author
DOI No:

ABSTRACT:
A new sustained release microencapsulated drug delivery system employing bhara gum derived from Terminalia bellerica (roxb) has been proposed in this present study. The microcapsules were formulated by ionic gelation technique using famotidine as the model drug and were evaluated for particle size, sphericity measurement, yield percentage, drug entrapment efficiency, wall thickness, swelling property, in vitro drug release profile and drug release kinetic study. The effect of different drug: bhara gum ratio on in vitro drug release profile was examined and compared with guar gum remaining all the parameters constant. The gum microcapsules with good structure and satisfactory yield were produced. Microcapsules employing bhara gum exhibited slow release of famotidine over 10 hr. Fickian release was observed from most of the formulation with bhara gum. It was concluded that the gum possess substantial release controlling properties that could be used for sustained drug delivery.
KEYWORDS:
Swelling properties, kinetics, matrices, mucilage.
Cite:
Nayak Bhabani Shankar, Nayak Udaya Kumar, Patro K Balakrishna, Rout Prasant Kumar. Design and Evaluation of Controlled Release Bhara Gum Microcapsules of Famotidine for Oral Use. Research J. Pharm. and Tech. 1(4): Oct.-Dec. 2008;Page 433-436.
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