Journal :   Research Journal of Pharmacy and Technology

Volume No. :   1

Issue No. :  4

Year :  2008

Pages :   398-400

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Hepatoprotective Activity of Aerva lanata Linn. Against Paracetamol Induced Hepatotoxicity in Rats



Address:   Manokaran S1*, Jaswanth A1, Sengottuvelu S2 , Nandhakumar J2, Duraisamy R2, Karthikeyan D2 and Mallegaswari R3
1Srikrupa Institute Pharmaceutical Sciences, Velkatta Village, Medak District, Andhra Pradesh, India.
2 Nandha College of Pharmacy and Research Institute, Koorapalayam Pirivu, Perundurai Main Road, Erode-638052,
3KM College of Pharmacy, Melur Main Road, Uthankudi Post, Madurai-625107, Tamil Nadu, India
*Corresponding Author
DOI No:

ABSTRACT:
The present study was conducted to evaluate the hepatoprotective activity of hydroalcoholic extract of Aerva lanata against paracetamol induced liver damage in rats. The hydroalcoholic extract of Aerva lanata (600mg/kg) was administered orally to the animals with hepatotoxicity induced by paracetamol (3gm/kg). Silymarin (25mg/kg) was given as reference standard. All the test drugs were administered orally by suspending in 0.5% Carboxy methyl cellulose solution. The plant extract was effective in protecting the liver against the injury induced by paracetamol in rats. This was evident from significant reduction in serum enzymes alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and bilirubin. It was concluded from the result that the hydroalcoholic extract of Aerva lanata possesses hepatoprotective activity against paracetamol induced hepatotoxicity in rats.
KEYWORDS:
Aerva lanata, Paracetamol, hepatoprotetive and hepatotoxicity.
Cite:
Manokaran S, Jaswanth A, Sengottuvelu S, Nandhakumar J, Duraisamy R, Karthikeyan D, Mallegaswari R. Hepatoprotective Activity of Aerva lanata Linn. Against Paracetamol Induced Hepatotoxicity in Rats. Research J. Pharm. and Tech. 1(4): Oct.-Dec. 2008;Page 398-400.
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