Journal :   Research Journal of Pharmacy and Technology

Volume No. :   1

Issue No. :  4

Year :  2008

Pages :   381-385

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Study of Different Crystal Habits Formed by Recrystallization Process and Study Effect of Variables



Address:   Praveen Chaudhari 1, Pravin Uttekar2, Nishant Waria2 and Amit Ajab2
1Progressive Education Society’s, Modern College of Pharmacy, Sector no 21, Yamunanagar, Nigdi, Pune-44, (MS) India.
2Padm. Dr. D. Y. Patil Institute of Pharmaceutical Science and Research, Pimpri, Pune-18, (MS) India.
*Corresponding Author
DOI No:

ABSTRACT:
Nimesulide crystals recrystallized from methanol, ethanol and DMSO solutions under different conditions (cooling rate or crystallization temperature, ultrasonication techniques). Scanning electron microscopy used to study crystal habit and X-ray powder diffractometry, FT-IR spectrometry and differential scanning calorimetry were used to investigate the physical characteristics of the crystals. Recrystallization produces needle shape crystals with methanol and ethanol and irregular rod shape with DMSO. Size of crystals form at cool and heat temperature are small. X-ray diffraction spectra and differential scanning calorimetry studies show polymorphic change. Ultrasound can induce nucleation in conditions where spontaneous primary nucleation cannot occur. This phenomenon results in a reduction in particle size but no effect on crystal habit.
KEYWORDS:
Nimesulide; Recrystallization; Physicochemical characterization; Crystallization; Crystal habit; Crystal shape; saturated solubility.
Cite:
Praveen Chaudhari, Pravin Uttekar, Nishant Waria, Amit Ajab. Study of Different Crystal Habits Formed by Recrystallization Process and Study Effect of Variables. Research J. Pharm. and Tech. 1(4): Oct.-Dec. 2008;Page 381-385.
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