Journal :   Research Journal of Pharmacy and Technology

Volume No. :   1

Issue No. :  4

Year :  2008

Pages :   377-380

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Development and In-vitro Evaluation of Mucoadhesive Buccal Tablets of Domperidone



Address:   Balamurugan M1, Saravanan VS1, Ganesh P*1, Senthil SP1, Hemalatha PV1 and Sudhir Pandya2
1The Erode College of Pharmacy, Erode (TN) India
2Nulife Pharmaceuticals, Pune (MS) India
*Corresponding Author
DOI No:

ABSTRACT:
Mucoadhesive buccal tablet of Domperidone were fabricated with objective of avoiding first pass metabolism and to improve its bioavailability with reduction in dosing frequency. The mucoadhesive polymers used in the formulations were Carbopol 934P, Methocel K4M, MethocelE15LV and Chitosan. Tablets were prepared by direct compression method using polymer in different ratios. The formulations were characterized for swelling index, in-vitro bioadhesion strength and in-vitro release studies. The best mucoadhesive performance and in- vitro drug release profile were exhibited by the tablet containing chitosan and Methocel K4M in ratio of 1:1. It was observed that the optimized formulation follows Hixson Crowel release kinetics.
KEYWORDS:
Buccal delivery, Chitosan, Domperidone, Mucoadhesive.
Cite:
Balamurugan M, Saravanan VS, Ganesh P, Senthil SP, Hemalatha PV, Sudhir Pandya. Development and In-vitro Evaluation of Mucoadhesive Buccal Tablets of Domperidone. Research J. Pharm. and Tech. 1(4): Oct.-Dec. 2008;Page 377-380.
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