Journal :   Research Journal of Pharmacy and Technology

Volume No. :   1

Issue No. :  4

Year :  2008

Pages :   513-515

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Spectrophotometric Method for Simultaneous Estimation of Amlodipine Besylate and Bisoprolol Fumarate in Pharmaceutical Preparations



Address:   RB Kakde*, VH Kotak, AG Barsagade, NK Chaudhary and DL Kale
Department of Pharmaceutical Sciences, RTM Nagpur University, Campus Nagpur (M.S) India. 440033
*Corresponding Author
DOI No:

ABSTRACT:
Simple spectrophotometric method has been developed for simultaneous estimation of amlodipine besylate and bisoprolol fumarate in combined dosage form. The method employed simultaneous equation method for analysis using 10% methanol as a solvent. The two wavelengths 222 nm and 365 nm were selected for estimation of bisoprolol fumarate and amlodipine besylate respectively. Linearity was observed in the concentration range of 5-100 µg/ml for both the drugs amlodipine besylate and bisoprolol fumarate. The recovery studies ascertained the accuracy of the proposed method and the results were validated as per ICH guidelines. The method can be employed for estimation of pharmaceutical formulations with no interference from any other excipients and diluents.
KEYWORDS:
Amlodipine besylate, Bisoprolol fumarate, Simultaneous equation method.
Cite:
RB Kakde, VH Kotak, AG Barsagade, NK Chaudhary, DL Kale. Spectrophotometric Method for Simultaneous Estimation of Amlodipine Besylate and Bisoprolol Fumarate in Pharmaceutical Preparations. Research J. Pharm. and Tech. 1(4): Oct.-Dec. 2008; Page 513-515.
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