Journal :   Research Journal of Pharmacy and Technology

Volume No. :   1

Issue No. :  3

Year :  2008

Pages :   211-214

ISSN Print :  0974-3618

ISSN Online :  0974-360X


Registration

Allready Registrered
Click to Login

Simultaneous RP-HPLC Method for Estimation of Ezetimibe and Simvastatin in Bulk and Dosage Forms



Address:   R Siva Kumar*, MR Santhanakrishnan, P Kumar Nallasivan and R Venkatanarayanan
Dept. Pharma. Analysis, RVS College of Pharmaceutical Sciences, Sulur, Coimbatore- 641 402. Tamilnadu, India.
* Corresponding Author
DOI No:

ABSTRACT:
A simple, specific, accurate, precise, rapid and reproducible reverse HPLC method has been developed for the simultaneous estimation of ezetimibe and simvastatin in bulk and tablet dosage forms using C18 column (symmetry, 4.6 mm x 25 cm) in isocratic mode with methanol: water (95:05 v/v) as a mobile phase with the detection wavelength of 248 nm and the flow rate was 0.8 ml/ min. The retention time of ezetimibe and simvastatin was found to 3.2 min and be 4.9 min, respectively. Linearity of the ezetimibe and simvastatin was found in the range of 5-70 µ g/ml and 5 - 50 µ g/ml, respectively. The recoveries of ezetimibe and simvastatin were found to be in the range of 99.27-101.10% and 99.63- 100.50%, respectively. The proposed method was validated suitably and can be used for routine analysis.
KEYWORDS:
Simultaneous estimation, RP-HPLC method, Simvastatin, Ezetimibe.
Cite:
R Siva Kumar, MR Santhanakrishnan, P Kumar Nallasivan, R Venkatanarayanan. Simultaneous RP-HPLC Method for Estimation of Ezetimibe and Simvastatin in Bulk and Dosage Forms. Research J. Pharm. and Tech. 1(3): July-Sept. 2008; Page 211-214.
[View HTML]      [View PDF]



Visitor's No. :   365763