Journal :   Research Journal of Pharmacy and Technology

Volume No. :   1

Issue No. :  3

Year :  2008

Pages :   197-200

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Formulation Development and Evaluation of Glibenclamide Microcapsules Using Solvent Evaporation Technique



Address:   Shivhare UD*1, Kale MK1, Bhusari KP1, Madankar VS1 and Godbole MD2
1Sharad Pawar College of Pharmacy, Hingna Road, Wanadogri, Nagpur-440110.
2Kamla Nehru College of Pharmacy, Borkhedi (Gate), Butibori, Nagpur-441108.
DOI No:

ABSTRACT:
In the present study, microcapsules containing glibenclamide were prepared by solvent evaporation method and characterized by sieve analysis and scanning electron microscopy. The microcapsules were analyzed for % encapsulation efficiency, physical properties and in-vitro release pattern. Different batches of microcapsules were prepared by altering the drug:polymer ratio. The size of microcapsules were in the range of 180-250 ยต m they were spherical in shape as evidenced by photo micrographs and scanning electron microscopy. The % drug entrapment was in the range of 58-83% and showed sustained drug release over a period of 12 hour.
KEYWORDS:
Microcapsules, glibenclamide, solvent evaporation.
Cite:
Shivhare UD, Kale MK, Bhusari KP, Madankar VS, Godbole MD. Formulation Development and Evaluation of Glibenclamide Microcapsules Using Solvent Evaporation Technique. Research J. Pharm. and Tech. 1(3): July-Sept. 2008; Page 197-200.
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