Journal :   Research Journal of Pharmacy and Technology

Volume No. :   1

Issue No. :  3

Year :  2008

Pages :   193-196

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Development and Evaluation of Sustained Release Matrix Tablets Using Natural Polymer as Release Modifier



Address:   LP Hingmire*, VN Deshmukh and DM Sakarkar
Department of Industrial Pharmacy, S. N. Institute of Pharmacy, Pusad. Dist: Yavatmal- 445 204. MS. India.
* Corresponding Author
DOI No:

ABSTRACT:
In the present investigation, an attempt has been made to increase therapeutic efficacy, reduce frequency of administration, and improve patient compliance, by developing sustained release matrix tablets of diclofenac sodium using natural polymers such as Xanthan gum, locust bean gum, sodium alginate. Sustained release matrix tablets of diclofenac sodium, were developed by using different drug: polymer ratios, such as 1:0.5; 1:1 and 1:1.5. Xanthan gum, locust bean gum, sodium alginate, combination of locust and xanthan, locust and sodium alginate were used as matrix former, the tablets were compressed by direct compression method using 8 mm flat faced punches. Compressed tablets were evaluated for uniformity of weight, content of active ingredient, friability, hardness, thickness, swelling index and in vitro dissolution using paddle method, and swelling index. All the formulations showed compliance with pharmacopoeial standards. Among these formulations, formulation containing combination of locust bean gum and Xanthan gum (6:4) showed sustained release of drug for 12 hours with release of 98.95 %. Optimized formulation was subjected toaccelrated stability studies. Thus, locust bean and Xanthan gum combination can be used as an effective matrix former, to extend the release of diclofenac sodium.
KEYWORDS:
Sustained release, Xanthan gum, locust bean gum, sodium alginate, diclofenac sodium.
Cite:
LP Hingmire, VN Deshmukh, DM Sakarkar. LP Hingmire, VN Deshmukh, DM Sakarkar. Development and Evaluation of Sustained Release Matrix Tablets Using Natural Polymer as Release Modifier. Research J. Pharm. and Tech. 1(3): July-Sept. 2008; Page 193-196.
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