Journal :   Research Journal of Pharmacy and Technology

Volume No. :   1

Issue No. :  3

Year :  2008

Pages :   187-192

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Effect of Cross-linking Agent on the Release of Drug from the Transdermal Matrix Patches of Tramadol Hydrochloride.



Address:   Kevin C Garala1, Romal J Garala2, Harinath N More1 and Anil J Shinde1*. 1Department of Pharmaceutics, Bharati Vidyapeeth College of Pharmacy, Kolhapur-413016, Maharashtra, India.
2Department of Pharmaceutics, Padm. Dr.DY.Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Maharashtra, India.
* Corresponding Author
DOI No:

ABSTRACT:
The present work was designed to develop suitable transdermal matrix patches of Tramadol hydrochloride, a non- steroidal anti-inflammatory drug, using hydroxy propyl methyl cellulose (HPMC) and Eudragit RS 100 with triethyl citrate as a plasticizer in group A and in group B, other than HPMC and Eudragit RS 100, cross-linking agent, succinic acid was added. A 32 full factorial design was employed for both groups. The concentration of HPMC and Eudragit RS- 100 were used as independent variables, while percentage drug release was selected as dependent variable. Physical evaluation was performed such as moisture content, moisture uptake, tensile strength, flatness and folding endurance. In vitro diffusion studies were performed using cellulose acetate membrane (pore size 0.45 µ ) in a Franz’s diffusion cell. The concentration of diffused drug was measured using UV-visible spectrophotometer (Jasco V-530) at ? max 272 nm. The experimental results shows that the patch containing HPMC in higher proportion gives increase in the release of drug and patches containing cross linking agent shows more release than those do not contains succinic acid.
KEYWORDS:
Tramadol hydrochloride (TH), Cross linking agent, Transdermal delivery.
Cite:
Kevin C Garala, Romal J Garala, Harinath N More, Anil J Shinde. Effect of Cross-linking Agent on the Release of Drug from the Transdermal Matrix Patches of Tramadol Hydrochloride. Research J. Pharm. and Tech. 1(3): July-Sept. 2008; Page 187-192.
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