Journal :   Research Journal of Pharmacy and Technology

Volume No. :   1

Issue No. :  3

Year :  2008

Pages :   155-160

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Poor Bioavailability of Rifampicin- A Global Emergency



Address:   Satish Balkrishna Bhise* and Sevukarajan Mookkan
Department of Biopharmaceutics, Government College of pharmacy, Karad-415124(M.S). India.
* Corresponding Author
DOI No:

ABSTRACT:
The use of Fixed dose combinations (FDCs) of antitubercular drugs in the short course chemotherapy of tuberculosis is being promoted internationally. However poor bioavailability of rifampicin has been perceived as a major bottleneck in successful treatment of tuberculosis. It perhaps is amongst one of the contributory factor which may lead to increasing resistance to anti-tubercular drugs. The present article critically focuses on various probable physical and/or chemical reasons responsible for poor/variable bioavailability of rifampicin in FDC and suggests the various approaches which may be successfully employed to overcome the aforementioned problems associated with rifampicin in FDCs.
KEYWORDS:
Rifampicin, FDC, Bioavailability.
Cite:
Satish Balkrishna Bhise, Sevukarajan Mookkan. Poor Bioavailability of Rifampicin- A Global Emergency. Research J. Pharm. and Tech. 1(3): July-Sept. 2008; Page 155-160.
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