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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   1

Issue No. :  2

Year :  2008

Pages :   83-85

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Simultaneous Estimation of Atorvastatin calcium and Nicotinic acid from Tablet Formulation

Address:   S. Pillai1, I.Singhvi1 and Mousumi Kar2
1Pacific College of Pharmacy, Air port Road, Pratap Nagar Extension, Udaipur (Raj) 313 001
2Department of Pharmaceutical Sciences, Mohan Lal Sukhadia University, Udaipur (Raj) 313 001
* Corresponding Author

Three simple, accurate, economical and reproducible UV spectrophotometric methods for simultaneous estimation of two component drug mixture of atorvastatin calcium and nicotinic acid from combined tablet dosage form have been developed. First developed method involves formation and solving of simultaneous equations using 254.0 nm and 270.0 nm as two wavelengths. Second method is based on two wavelength calculation, wavelengths selected for estimation of atorvastatin calcium were 260.4 nm and 275.6 nm and for nicotinic acid 240.4 nm and 265.2 nm. Third method was developed making use of first order derivative spectroscopy using 233.2 nm and 304.4 nm as zero crossing points for estimation of nicotinic acid and atorvastatin calcium respectively. The results of analysis have been validated statistically and by recovery studies.
Spectrophotometric, Atorvastatin calcium, Nicotinic acid.
S. Pillai, I.Singhvi, Mousumi Kar. Simultaneous Estimation of Atorvastatin calcium and Nicotinic acid from Tablet Formulation. Research J. Pharm. and Tech. 1(2): April-June. 2008;Page83-85.
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