Journal :   Research Journal of Pharmacy and Technology

Volume No. :   1

Issue No. :  2

Year :  2008

Pages :   80-82

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Simultaneous Estimation of Metoprolol and Amlodipine from Tablet Dosage Form



Address:   Sohan S. Chitlange*1, Md. Imran1, Sagar B. Wankhede1 and Dinesh M. Sakarkar2
1Pad. Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune-411 018.
2S. N. Institute of Pharmacy, Pusad Dist Yawatmol.
*Corresponding Author
DOI No:

ABSTRACT:
Simple spectrophotometric methods have been developed for simultaneous estimation of Metoprolol (MET) and Amlodipine (AMD) in two component tablet formulation. The methods employed are Absorbance corrected for interference method and Area under curve method. For Absorbance corrected for interference method the working wavelengths selected are 224 nm for MET and 362.5 nm for AMD. Similarly for Area under curve method the working wavelength ranges selected are 234-242 nm (?1 – ?2) for AMD and 218-228 nm (?3 – ?4) for MET. For both the methods linearity was observed in the concentration range of 10-50 ?g/ml for MET and 4-20 ?g/ml for AMD. The recovery studies confirmed the accuracy of proposed method and the methods were validated as per ICH guidelines.
KEYWORDS:
Metoprolol; Amlodipine; Absorbance corrected for interference; Area under curve.
Cite:
Sohan S. Chitlange, Imran, Sagar B. Wankhede, Dinesh M. Sakarkar. Simultaneous Estimation of Metoprolol and Amlodipine from Tablet Dosage Form. Research J. Pharm. and Tech. 1(2): April-June. 2008Page 80-82.
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