Journal :   Research Journal of Pharmacy and Technology

Volume No. :   1

Issue No. :  1

Year :  2008

Pages :   25-28

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Simultaneous RP-HPLC Method for Estimation of Ezetimibe and Fenofibrate in Synthetic mixture



Address:   H.I. Pawar*, Lata Kothapalli, Asha Thomas, R.K Nanda and Shivaji Mare
Department of Pharmaceutical Chemistry, Pad. Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune-411 018
*Corresponding Author
DOI No:

ABSTRACT:
A simple precise, accurate and validated reverse phase HPLC method has been developed for the simultaneous estimation of ezetimibe and fenofibrate in bulk and in synthetic mixture using C18 column (Kromosil, 4.6mm x 25 cm, 5µm) with acetonitrile: 0.05 M ammonium acetate buffer (85: 15 v/v) as a mobile phase, at a flow rate of 1.3 ml/min and detection was done at 253.0 nm. The retention time for ezetimibe and fenofibrate was found to be 2.41+ 0.011and 6.03+ 0.023 min, respectively. Linearity of ezetimibe and fenofibrate was found in the range of 2-20 µg/ml and 16-80 µg/ml respectively. The percentage assay of ezetimibe and fenofibrate was found between 99% to 101 %.The statistical parameters were found within range
KEYWORDS:
Fenofibrate, Ezetimibe, RP-HPLC method.
Cite:
H.I. Pawar, Lata Kothapalli, Asha Thomas, R.K Nanda, Shivaji Mare. Simultaneous RP-HPLC Method for Estimation of Ezetimibe and Fenofibrate in Synthetic mixture. Research J. Pharm. and Tech. 1(1): Jan.-Mar. 2008; Page 25-28.
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