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Journal :   Research Journal of Pharmacy and Technology

Volume No. :   1

Issue No. :  1

Year :  2008

Pages :   22-24

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Synthesis and Analgesic Activity of Some Mannich Bases of 6-Substituted-2-Aminobenzothiazole.

Address:   D. S. Bele1 and I. Singhvi2
1B N Girls’ College of Pharmacy, Udaipur (Raj.) 313 001
2Pacific College of Pharmacy, Pratap Nagar, Airport Road, Udaipur (Raj) 313 003
* Corresponding Author

Mannich reaction between 6-substituted-2-aminobenzothiazole and 1-(5- substituted-1H-1,2,4-triazol-1-yl) ethanone in presence of formalin yield ten new mannich bases. All the synthesized compounds were characterized by UV, IR and 1H-NMR spectroscopy. The analgesic activity of the synthesized compounds was evaluated, on albino mice, by hot plate method using acetyl salicylic acid as reference standard. The present investigation results into compounds possessing good analgesic activity.
Mannich reaction, 2-aminobenzothiazole, Triazole, analgesic.
D. S. Bele, I. Singhvi. Synthesis and Analgesic Activity of Some Mannich Bases of 6-Substituted-2-Aminobenzothiazole.. Research J. Pharm. and Tech. 1(1): Jan.-Mar. 2008; Page 22-24.
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