Journal :   Research Journal of Pharmacy and Technology

Volume No. :   1

Issue No. :  1

Year :  2008

Pages :   18-21

ISSN Print :  0974-3618

ISSN Online :  0974-360X


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Development of RP-HPLC Method for Estimation of Carvedilol in Tablet Formulations



Address:   Mahaveer Singh1,*, S.G. Kashkhedikar1, Love Soni1, Abhinav Garg1, Tripti Gandhi2 and Amrish Patel2
1Department of Pharmacy, Shri G.S. Institute of Technology and Science, Indore 452003, India.
2Department of Analytical Development, Torrent Pharmaceutical Ltd., Ahmedabad, India.
*Corresponding Author
DOI No:

ABSTRACT:
A simple and sensitive reverse phase high performance liquid chromatographic method has been developed for estimation of Carvedilol in pharmaceutical formulation. The quantification was carried out using Inertsil C8 150 mm* 4.6mm, 5?m column in isocratic mode. The mobile was made up of buffer and Acetonitrile in the ratio of 65:35 (v/v). Potassium dihydrogen phosphate was used for preparation of buffer. The detection was carried out at 240nm and linearity was found to be in the range of 2 to10 ?g/ml. The method was duly validated as per ICH guidelines.
KEYWORDS:
RP-HPLC, Carvedilol, pharmaceutical dosage form Acetonitrile.
Cite:
Mahaveer Singh, S.G. Kashkhedikar, Love Soni, Abhinav Garg Tripti Gandhi, Amrish Patel. Development of RP-HPLC Method for Estimation of Carvedilol in Tablet Formulations. Research J. Pharm. and Tech. 1(1): Jan.-Mar. 2008; Page 18-21.
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